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2010•African Journal of Microbiology ResearchOpen access

The status of serum procalcitonin in sepsis and non- infectious systemic inflammatory response syndrome

Hamidreza Kouhpayeh, Mohammad Hashemi, Mohammad Naderi, Seyed Hassan Mozafar

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Abstract

Procalcitonin (PCT) is a marker of the inflammatory response to infection and not released in viral disease. The aim of the present study was to determine the level of PCT in sepsis and non-infectious systemic inflammatory response syndrome (SIRS) We determined the level of serum PCT in 50 sepsis and 50 non-infectious SIRS cases, using semiquantitative PCT-Q kit. The frequency of PCT positivity was significantly higher in sepsis than non-infectious SIRS (P < 0.001). Using cut off value of 2 ng/ml for PCT, the sensitivity, specificity, positive predictive value and negative predictive value for serum PCT in distinguishing sepsis from non-infectious SIRS were 88.0, 90.0, 89.8 and 88.2%, respectively. The serum PCT is a reliable marker for distinguishing sepsis from non-infectious SIRS in association with clinical judgment and other paraclinical findings.   Key words: Sepsis, SIRS, procalcitonin.

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What this paper is about

Procalcitonin (PCT) is a marker of the inflammatory response to infection and not released in viral disease. The aim of the present study was to determine the level of PCT in sepsis and non-infectious systemic inflammatory response syndrome (SIRS) We determined the level of serum PCT in 50 sepsis and 50 non-infectious SIRS cases, using semiquantitative PCT-Q kit. The frequency of PCT positivity was significantly higher in sepsis than non-infectious SIRS (P < 0.001). Using cut off value of 2 ng/ml for PCT, the sensitivity, specificity, positive predictive value and negative predictive value for serum PCT in distinguishing sepsis from non-infectious SIRS were 88.0, 90.0, 89.8 and 88.2%, respectively. The serum PCT is a reliable marker for distinguishing sepsis from non-infectious SIRS in association with clinical judgment and other paraclinical findings.   Key words: Sepsis, SIRS, procalcitonin.

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Available abstract

Procalcitonin (PCT) is a marker of the inflammatory response to infection and not released in viral disease. The aim of the present study was to determine the level of PCT in sepsis and non-infectious systemic inflammatory response syndrome (SIRS) We determined the level of serum PCT in 50 sepsis and 50 non-infectious SIRS cases, using semiquantitative PCT-Q kit. The frequency of PCT positivity was significantly higher in sepsis than non-infectious SIRS (P < 0.001). Using cut off value of 2 ng/ml for PCT, the sensitivity, specificity, positive predictive value and negative predictive value for serum PCT in distinguishing sepsis from non-infectious SIRS were 88.0, 90.0, 89.8 and 88.2%, respectively. The serum PCT is a reliable marker for distinguishing sepsis from non-infectious SIRS in association with clinical judgment and other paraclinical findings.   Key words: Sepsis, SIRS, procalcitonin.

Key concepts: Procalcitonin, Systemic inflammatory response syndrome, Sepsis, Medicine, Predictive value, Immunology, Internal medicine, Gastroenterology

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