Solitary Fibrous Tumor of the Kidney - A Report of Two Cases with Review of Literature -
Sun A. Kim, Jung Eun Hwang, Jae Y. Ro, Kyung-Ja Cho, Cheryn Song, Mi-Jung Kim
Abstract
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Sun A. Kim, Jung Eun Hwang, Jae Y. Ro, Kyung-Ja Cho, Cheryn Song, Mi-Jung Kim
Abstract
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Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm usually occurring in the pleura.Kidney is one of the rarest sites for SFT.We report here on two cases of renal SFT found in 30-year-old and 33-year-old men with review of the literatures.Both cases manifested as well-enhanced solid masses in kidney and radical nephrectomies were done.The tumors consisted of bland-looking spindle cells arranged in short, ill-defined fascicles and storiform pattern with characteristic hemangiopericytoma-like blood vessels.The tumor cells were strongly positive for CD34 and CD99, focally positive for bcl-2, and negative for cytokeratin and human melanoma black-45 on immunohistochemical stainings.Possibility of SFT should be considered in the differential diagnosis of a renal mass which consists of benign-looking spindle cells and hemangiopericytomatous blood vessels.Immunohistochemical staining for CD34 is essential to confirm the renal solitary fibrous tumor.
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Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm usually occurring in the pleura.Kidney is one of the rarest sites for SFT.We report here on two cases of renal SFT found in 30-year-old and 33-year-old men with review of the literatures.Both cases manifested as well-enhanced solid masses in kidney and radical nephrectomies were done.The tumors consisted of bland-looking spindle cells arranged in short, ill-defined fascicles and storiform pattern with characteristic hemangiopericytoma-like blood vessels.The tumor cells were strongly positive for CD34 and CD99, focally positive for bcl-2, and negative for cytokeratin and human melanoma black-45 on immunohistochemical stainings.Possibility of SFT should be considered in the differential diagnosis of a renal mass which consists of benign-looking spindle cells and hemangiopericytomatous blood vessels.Immunohistochemical staining for CD34 is essential to confirm the renal solitary fibrous tumor.
Key concepts: Medicine, Pathology, Solitary fibrous tumor, Kidney, Internal medicine, Biology, Genetics, CD34