Hepatoprotective activity of aqueous extract of Khaya senegalensis bark in rats

This study was designed to evaluate the hepatoprotective activity of Khaya senegalensis bark (Meliaceae) against CCl 4- induced liver damage in rats. Aqueous extract of the bark of K. senegalensis was orally administered to rats at 250 and 500 mg/kg for five days which was significantly alleviate the damage that induced to liver by CCL 4. The levels of AST, ALT, ALP, bilirubin, total protein and albumin, in groups treated by extract were significantly decreased compared to CCL 4 group; These findings were strongly confirmed by histopathological studies of liver tissue in comparison with the group treated by the standard drug silymarin. This study indicates that, the aqueous extract of K. senegalensis bark possesses hepatoprotective ingredients.