FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF NOVEL THIENOPYRIMIDINES AND TRIAZOLOTHIENOPYRIMIDINES LOADED SOLID LIPID NANOPARTICLES

Thienopyrimidines and triazolothienopyrimidines loaded solid lipid nanoparticles (SLNs) were produced by microemulsion method. All the formulations were subjected to particle size analysis, zeta potential, compound entrapment efficiency and in vitro release studies. The SLNs formed were in nano-size range with maximum entrapment efficiency. Formulation with 195 nm in particle size and 84.20% of compound entrapment was subjected to scanning electron microscopy (SEM) for surface morphology, differential scanning calorimetry (DSC) for thermal analysis and short term stability studies. SEM confirms that the SLNs are circular in shape. The compound release behavior from SLN suspension exhibited biphasic pattern with an initial burst and prolonged release over 24 h.