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1979•The Journal of Clinical Endocrinology & MetabolismRequires access

REDUCED GONADOTROPIN SECRETION IN POSTMENOPAUSAL WOMEN DURING TREATMENT WITH A STIMULATORY LRH ANALOGUE

Christer Bergquist, Sven Johan Nillius, LEIF E. WIDE

Open publisher page 66 citations

Abstract

The potent and long-acting LRH agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 microgram to 5 postmenopausal women for a period of 10 days. The LRH analogue produced a significant decrease in both the basal FSH and LH levels and the gonadotropin responses to the agonist. The estrogen levels in serum remained unchanged during the study period. The results suggest that D-Ser(TBU)6-EA10-LRH has a direct inhibitory effect at the pituitary level.

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What this paper is about

The potent and long-acting LRH agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 microgram to 5 postmenopausal women for a period of 10 days. The LRH analogue produced a significant decrease in both the basal FSH and LH levels and the gonadotropin responses to the agonist. The estrogen levels in serum remained unchanged during the study period. The results suggest that D-Ser(TBU)6-EA10-LRH has a direct inhibitory effect at the pituitary level.

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OpenAlex reports 66 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The potent and long-acting LRH agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 microgram to 5 postmenopausal women for a period of 10 days. The LRH analogue produced a significant decrease in both the basal FSH and LH levels and the gonadotropin responses to the agonist. The estrogen levels in serum remained unchanged during the study period. The results suggest that D-Ser(TBU)6-EA10-LRH has a direct inhibitory effect at the pituitary level.

Key concepts: Internal medicine, Endocrinology, Agonist, Gonadotropin, Basal (medicine), Estrogen, Gonadotropin-releasing hormone agonist, Gonadotropin-releasing hormone

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REDUCED GONADOTROPIN SECRETION IN POSTMENOPAUSAL WOMEN DURING TREATMENT WITH A STIMULATORY LRH ANALOGUE — Research Paper | ScholarLens