2012•Memórias do Instituto Oswaldo CruzOpen access

The prevalence of human cytomegalovirus DNA in gliomas of Brazilian patients

Renata F. Fonseca, Márcia Tie Kawamura, José Antônio de Oliveira, Anselmo Teixeira, Gilda Alves, Maria da Glória Carvalho

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Abstract

Members of the Herpesviridae family have been implicated in a number of tumours in humans. At least 75% of the human population has had contact with cytomegalovirus (HCMV). In this work, we screened 75 Brazilian glioma biopsies for the presence of HCMV DNA sequences. HCMV DNA was detected in 36% (27/75) of the biopsies. It is possible that HCMV could be a co-factor in the evolution of brain tumours.

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Key concepts: Human cytomegalovirus, Cytomegalovirus, Herpesviridae, Virology, Population, DNA, Glioma, Biology