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2009•Dissolution TechnologiesOpen access

Predicting Food Effects on Drug Release from Extended-Release Oral Dosage Forms Containing a Narrow Therapeutic Index Drug

Sandra Klein

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Abstract

With the various types of oral extended-release (ER) dosage forms available, it is a challenge to accurately predict their in vivo behavior. If therapeutically appropriate, an oral ER dosage form should provide consistent drug release over the entire dosing interval, regardless of when it is given in relation to meal

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What this paper is about

With the various types of oral extended-release (ER) dosage forms available, it is a challenge to accurately predict their in vivo behavior. If therapeutically appropriate, an oral ER dosage form should provide consistent drug release over the entire dosing interval, regardless of when it is given in relation to meal

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OpenAlex reports 25 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

With the various types of oral extended-release (ER) dosage forms available, it is a challenge to accurately predict their in vivo behavior. If therapeutically appropriate, an oral ER dosage form should provide consistent drug release over the entire dosing interval, regardless of when it is given in relation to meal

Key concepts: Drug, Pharmacology, Therapeutic index, Immediate release, Dosage form, Medicine, Chemistry

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