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2010•Cold Spring Harbor Perspectives in BiologyOpen access

Understanding the Structure and Function of the Immunological Synapse

Michael L. Dustin, Arup K. Chakraborty, Andréy S. Shaw

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Abstract

The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is formed.

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What this paper is about

The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is formed.

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Available abstract

The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is formed.

Key concepts: Immunological synapse, Biology, Synapse, Neuroscience, Function (biology), T cell, Cell biology, Immune system

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