ScholarLens Back to search
2012•Dementia & NeuropsychologiaOpen access

Cognitive impairment in patients with clinically isolated syndrome

Carolina Fiorin Anhoque, Laurentino Biccas Neto, Simone Cristina Aires Domingues, Antônio Lúcio Teixeira, Renán Barros Domingues

Open full text 11 citations

Abstract

Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. METHODS: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. RESULTS: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. CONCLUSION: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.

Open-access reader

About this research paper

What this paper is about

Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. METHODS: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. RESULTS: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. CONCLUSION: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.

Why it matters

OpenAlex reports 11 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. METHODS: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. RESULTS: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. CONCLUSION: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.

Key concepts: Memory span, Verbal fluency test, Stroop effect, Audiology, Psychology, Wechsler Adult Intelligence Scale, Neuropsychology, Verbal memory

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Cognitive impairment in patients with clinically isolated syndrome — Research Paper | ScholarLens