1992•Journal of General VirologyRequires access
Infection of macaque monkeys with a chimeric human and simian immunodeficiency virus
Sayuri Sakuragi, Riri Shibata, R Mukai, Toshihiko Komatsu, Masashi Fukasawa, Hiroe Sakai, Jun-ichi Sakuragi, M. Kawamura, Kazuyasu Ibuki, M. Hayami, Akio Adachi
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Abstract
Two macaque monkeys were inoculated with a chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu and env genes of human immunodeficiency virus type 1. Infectious virus was recovered from one of the monkeys at 2 and 6 weeks post-infection. The hybrid nature of the isolated viruses was verified by Southern and Western blotting analyses. Both of the monkeys infected with the chimera elicited a humoral antibody response against the virus.