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2012•Russian Journal of Physical Chemistry BRequires access

Supercritical fluid chromatography and its application to analysis and preparation of high-purity compounds

Andrey S. Samokhin, Igor A. Revelsky, D. A. Chepelyansky, О. О. Паренаго, O. I. Pokrovskiy, F. D. Lepeshkin, Konstantin B. Ustinovich, Alexander I. Revelsky

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Abstract

The principles of supercritical fluid chromatography (SFC) and its application in various fields are reviewed. A comparison of high-performance liquid chromatography (HPLC) and SFC is performed. In discussing the applications, emphasis is placed on the possibility of using SFC in analysis of impurities in pharmaceuticals and biologically important substances and in preparation of high-purity substances. In describing detectors for SFC, special attention is paid to mass-spectrometric detectors.

About this research paper

What this paper is about

The principles of supercritical fluid chromatography (SFC) and its application in various fields are reviewed. A comparison of high-performance liquid chromatography (HPLC) and SFC is performed. In discussing the applications, emphasis is placed on the possibility of using SFC in analysis of impurities in pharmaceuticals and biologically important substances and in preparation of high-purity substances. In describing detectors for SFC, special attention is paid to mass-spectrometric detectors.

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OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The principles of supercritical fluid chromatography (SFC) and its application in various fields are reviewed. A comparison of high-performance liquid chromatography (HPLC) and SFC is performed. In discussing the applications, emphasis is placed on the possibility of using SFC in analysis of impurities in pharmaceuticals and biologically important substances and in preparation of high-purity substances. In describing detectors for SFC, special attention is paid to mass-spectrometric detectors.

Key concepts: Supercritical fluid chromatography, Chromatography, Supercritical fluid, Chemistry, Impurity, High-performance liquid chromatography, Supercritical fluid extraction, Organic chemistry

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