1997•Nucleosides and NucleotidesRequires access

4-Cyano-2-butenyl Group: A New Type of Protecting Group in Oligonucleotide Synthesis via Phosphoramidite Approach

Vasulinga T. Ravikumar, Zacharia S. Cheruvallath, Douglas L. Cole

Abstract

4-Cyano-2-butenyl (CB) is a new type of protecting group for the intemucleotidic bonds in the synthesis of oligodeoxyribonucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild conditions by a δ-elimination pathway using aqueous ammonium hydroxide.

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Key concepts: Phosphoramidite, Oligonucleotide synthesis, Protecting group, Ammonium hydroxide, Chemistry, Group (periodic table), Oligonucleotide, Combinatorial chemistry