ScholarLens Back to search
2013•Journal of ChemistryOpen access

Modified Chitosan‐Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen

Rehab Abdeen, Nehal A. Salahuddin

Open full text 71 citations

Abstract

The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X‐ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6 Å to 19.6 Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions. The results revealed that ibuprofen was released from MMT, CS, and Mod‐CS/MMT steadily and was pH dependent.

Open-access reader

About this research paper

What this paper is about

The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X‐ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6 Å to 19.6 Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions. The results revealed that ibuprofen was released from MMT, CS, and Mod‐CS/MMT steadily and was pH dependent.

Why it matters

OpenAlex reports 71 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X‐ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6 Å to 19.6 Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions. The results revealed that ibuprofen was released from MMT, CS, and Mod‐CS/MMT steadily and was pH dependent.

Key concepts: Chemistry, Chitosan, Ibuprofen, Intercalation (chemistry), Nanocomposite, Drug delivery, In vitro, Chemical engineering

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Modified Chitosan‐Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen — Research Paper | ScholarLens