2004•Antimicrobial Agents and ChemotherapyOpen access

Antifungal Therapy of Murine Aspergillus terreus Infection

John R. Graybill, Steve Hernandez, Rosie A. Bocanegra, Laura K. Najvar

Abstract

Aspergillus terreus is a species which is being seen increasingly frequently and which is highly resistant to amphotericin B in vitro and clinically. We evaluated amphotericin B, caspofungin, and posaconazole in a murine model of acute invasive aspergillosis. Caspofungin and posaconazole both appeared beneficial and may be reasonable treatment alternatives for infection with A. terreus.

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Key concepts: Posaconazole, Caspofungin, Aspergillus terreus, Aspergillosis, Amphotericin B, Microbiology, Biology, Aspergillus