SUSCEPTIBILITY OF PSEUDOMONAS AERUGINOSA TO THIRD GENERATION CEPHALOSPORINS

Pseudomonas aeruginosa (Ps. aeruginosa ) is a nosocomial pathogen distributed worldwide. The organism is known as the causative agent of many diseases. The aim of this study was to determi ne susceptibility of Ps. aeruginosa to third generation cephalosporins (Ceftazidime, C eftriaxone, Cefotaxime, cefoprazone). Clinical specimens (n= 293 ) were collected from patients in different hospitals, including Khartoum Teaching Hospital, Ea r Nose Throat Hospital, Military Hospital and National Health La boratory. The patients including 55% males and 45% females aging lees than1 to 88 years. Ps. aeruginosa was recovered and identified by conventional metho ds. A total of 68 strains of Ps. aeruginosa were isolated from infected wounds 36 (53%), infected ears 24 (35%), and urine 8 (12%). The study showed that ceftazidime was the most effective (91%) followed by cefoperazone (47%), ceftriaxone (7%) and cefotaxime (3%). The results indicated no significant differences be tween isolates recovered from males or females (P>0.05).