1995•Journal of Magnetic Resonance ImagingRequires access

Cocaine‐induced changes in time course of regional cerebral blood volume and transit time as determined by dynamic MR imaging

Ka‐Loh Li, James N. Suojanen

Abstract

We examined cocaine-mediated change in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. Changes in MTT and rCBV in animals who had previously been given cocaine depended on the length of time between the last pretreatment injection and the acute injection and seemed to parallel cocaine-mediated changes in extracellular dopamine concentrations.

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Key concepts: Mean transit time, Cerebral blood volume, Transit time, Medicine, Transit (satellite), Nuclear medicine, Blood volume, Volume (thermodynamics)