2008•Cancer InvestigationRequires access
Prostate Tumor-Inducing Gene-1 Analysis in Human Prostate Cancer Cells and Tissue in Relation toMycoplasmaInfection
Bruna Scaggiante, Serena Bonin, Luigi Cristiano, Salvatore Siracusano, Giorgio Stanta, Barbara Dapas, Carlo Giansante, Nicola Fiotti, Gabriele Grassi
Open publisher page 6 citations
Abstract
The potential role of PTI-1, in the natural story of prostate adenocarcinoma remains to be fully determined. PTI-1 expression was evaluated in human prostate cancer cell lines and in paraffin-embedded archive tissues. PTI-1 expression was found in Mycoplasma infected but not in non-infected cells. The lack of PTI-1 expression was also confirmed in fixed and paraffin-embedded human cancer prostate biopsies. The overall data indicate that, in prostate tumor cell lines, PTI-1 presence parallels Mycoplasma infection suggesting that PTI-1 might not necessarily play a major role in the onset of prostate tumorigenesis.