1985•Journal of Analytical ToxicologyRequires access

Simultaneous Determination of Lidocaine, Mexiletine, Disopyramide, and Quinidine in Plasma by High Performance Liquid Chromatography

Leon J. Dusci, Laurence P. Hackett

Abstract

A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of variation were less than 4%.

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Available abstract

Key concepts: Disopyramide, Mexiletine, Quinidine, Lidocaine, Chromatography, Chemistry, Antiarrhythmic agent, High-performance liquid chromatography