2009•Antimicrobial Agents and ChemotherapyOpen access

In Vitro Activities of Trioxaquines against Schistosoma mansoni

Jérôme Boissier, F. Cosledan, Anne Robert, Bernard Meunier

Abstract

We report the in vitro activities of trioxaquines against larval and adult-stage schistosomes at 5 and 50 microg/ml, respectively. Such activities are equivalent to that of praziquantel, the major and rather unique drug currently used for the treatment of schistosomiasis. In this range of concentrations, artemisinin derivatives (artesunate and artemether) have no activity.

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Key concepts: Praziquantel, Artesunate, Artemisinin, Artemether, Schistosoma mansoni, Schistosomiasis, Anthelmintic, In vitro