ScholarLens Back to search
2005•Unpublished venueRequires access

IMMUNOHISTOCHEMICAL LOCALIZATION OF COX2 IN CELLS OF MAMMARY ADENOCARCINOMAS IN BITCHES AS RELATED TO TUMOUR MALIGNANCY GRADE

Marcin Nowak, J.A. Madej, Piotr Dzięgiel

Open publisher page 6 citations

Abstract

Using immunohistochemistry the localization and expression intensity of COX2 were evaluated in mammary adenocarcinomas in bitches. The obtained results were related to the tumour malignancy grades. Material for the studies was sampled in the course of surgery from bitches of various strains which developed the primary mammary tumour. In cytoplasm of mammary adenocarcinoma cells the presence of COX2 was disclosed in 74% of the examined tumours. Augmented expression of COX2 was noted in samples of tumours demonstrating high grades of malignancy. A moderate positive correlation was disclosed between expression of COX2 and the grade of histological malignancy (r = 0.41), which might point to the involvement of the enzyme in neoplastic transformation of cells in the mammary glands.

About this research paper

What this paper is about

Using immunohistochemistry the localization and expression intensity of COX2 were evaluated in mammary adenocarcinomas in bitches. The obtained results were related to the tumour malignancy grades. Material for the studies was sampled in the course of surgery from bitches of various strains which developed the primary mammary tumour. In cytoplasm of mammary adenocarcinoma cells the presence of COX2 was disclosed in 74% of the examined tumours. Augmented expression of COX2 was noted in samples of tumours demonstrating high grades of malignancy. A moderate positive correlation was disclosed between expression of COX2 and the grade of histological malignancy (r = 0.41), which might point to the involvement of the enzyme in neoplastic transformation of cells in the mammary glands.

Why it matters

OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Using immunohistochemistry the localization and expression intensity of COX2 were evaluated in mammary adenocarcinomas in bitches. The obtained results were related to the tumour malignancy grades. Material for the studies was sampled in the course of surgery from bitches of various strains which developed the primary mammary tumour. In cytoplasm of mammary adenocarcinoma cells the presence of COX2 was disclosed in 74% of the examined tumours. Augmented expression of COX2 was noted in samples of tumours demonstrating high grades of malignancy. A moderate positive correlation was disclosed between expression of COX2 and the grade of histological malignancy (r = 0.41), which might point to the involvement of the enzyme in neoplastic transformation of cells in the mammary glands.

Key concepts: Malignancy, Immunohistochemistry, Pathology, Adenocarcinoma, Cytoplasm, Mammary gland, Malignant transformation, Biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
IMMUNOHISTOCHEMICAL LOCALIZATION OF COX2 IN CELLS OF MAMMARY ADENOCARCINOMAS IN BITCHES AS RELATED TO TUMOUR MALIGNANCY GRADE — Research Paper | ScholarLens