1997•Unpublished venueRequires access

Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: a simulation study

Javier Sáiz, José María Ferrero, Javier Chorro, M. Monserrat, Vicente E. Torres, José María Ferrero, Nitish V. Thakor

Abstract

The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. The authors' results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast I/sub Na/ current may be partially responsible for the ERP prolongation.

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Key concepts: Refractory period, Subthreshold conduction, Train, Prolongation, Computer science, Electrical engineering, Physics, Medicine