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Comparison of Solid-Phase Extraction and Dialysis on Pretreatment Efficiency of Blood Urea Analysis

Hideharu Shintani

Open publisher page 9 citations

Abstract

Although the analysis of urea in blood using high-performance liquid chromatography has been reported, its automated solid-phase extraction (SPE) has not been reported. In addition to these two methods, dialysis may also be used to pretreat blood samples. The separation efficiency of automated SPE is discussed and compared with automated dialysis using a condensing column. The results indicate that automated SPE and dialysis have an almost identical separation efficiency for urea analysis. However, the dialysis technique is not as efficient for the removal of admixtures eluted after urea.

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What this paper is about

Although the analysis of urea in blood using high-performance liquid chromatography has been reported, its automated solid-phase extraction (SPE) has not been reported. In addition to these two methods, dialysis may also be used to pretreat blood samples. The separation efficiency of automated SPE is discussed and compared with automated dialysis using a condensing column. The results indicate that automated SPE and dialysis have an almost identical separation efficiency for urea analysis. However, the dialysis technique is not as efficient for the removal of admixtures eluted after urea.

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OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Although the analysis of urea in blood using high-performance liquid chromatography has been reported, its automated solid-phase extraction (SPE) has not been reported. In addition to these two methods, dialysis may also be used to pretreat blood samples. The separation efficiency of automated SPE is discussed and compared with automated dialysis using a condensing column. The results indicate that automated SPE and dialysis have an almost identical separation efficiency for urea analysis. However, the dialysis technique is not as efficient for the removal of admixtures eluted after urea.

Key concepts: Chemistry, Chromatography, Dialysis, Urea, Elution, Solid phase extraction, Extraction (chemistry), Biochemistry

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