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Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy.

Farshad Nassiri, Michael D. Cusimano, Bernd Walter Scheithauer, Fabio Rotondo, Alessandra Fazio, George M. Yousef, Luis V. Syro, Kálmán Kovács, Ricardo V. Lloyd

Open publisher page 301 citations

Abstract

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy.

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What this paper is about

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy.

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OpenAlex reports 301 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis and neovascularization. Several studies demonstrate the potential of endoglin in tumor diagnosis, prognosis, and therapy. This review details the structure and function of endoglin, and investigates the role of endoglin in angiogenesis and tumor diagnosis, prognosis, and therapy.

Key concepts: Endoglin, Angiogenesis, Neovascularization, Medicine, Cancer research, Transforming growth factor, Transforming growth factor beta, Pathology

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Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy. — Research Paper | ScholarLens