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Increase in Activity During Calorie Restriction Requires Sirt1

Danica Chen, Andrew D. Steele, Susan Lindquist, Leonard Guarente

Open publisher page 423 citations

Abstract

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

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What this paper is about

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

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OpenAlex reports 423 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

Key concepts: Calorie restriction, Regulator, Biology, Nicotinamide adenine dinucleotide, Sirtuin, Phenotype, Nicotinamide mononucleotide, Sirtuin 1

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