2013•MoleculesOpen access

Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum

Wenlong Wang, Li-Jun Song, Xia Chen, Xu-Ren Yin, Wen-Hua Fan, Gu-Ping Wang, Chuan-Xin Yu, Bainian Feng

Abstract

The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.

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Key concepts: Praziquantel, Schistosoma japonicum, Anthelmintic, Schistosoma, Pharmacology, Chemistry, Schistosomiasis, Schistosoma mansoni