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1989•Journal of Medical MicrobiologyRequires access

Cross-reaction of immune sera from patients with rickettsial diseases

Karim E. Hechemy, Didier Raoult, J A Fox, Yangsook Han, L B Elliott, Julia A. Rawlings

Open publisher page 87 citations

Abstract

Rickettsia rickettsii and Rickettsia conorii are the causative agents of two common and serious diseases, Rocky Mountain spotted fever and Mediterranean spotted fever, respectively. In patients naturally infected with either of these organisms, antibodies are produced which cross-react with antigens of the other so extensively that diagnostic tests usually cannot identify the causative agents. The results of this study indicate that serodiagnostic tests with antigen from one of these two organisms could be used to detect antibodies in patients with either of the two rickettsial diseases.

About this research paper

What this paper is about

Rickettsia rickettsii and Rickettsia conorii are the causative agents of two common and serious diseases, Rocky Mountain spotted fever and Mediterranean spotted fever, respectively. In patients naturally infected with either of these organisms, antibodies are produced which cross-react with antigens of the other so extensively that diagnostic tests usually cannot identify the causative agents. The results of this study indicate that serodiagnostic tests with antigen from one of these two organisms could be used to detect antibodies in patients with either of the two rickettsial diseases.

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OpenAlex reports 87 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Rickettsia rickettsii and Rickettsia conorii are the causative agents of two common and serious diseases, Rocky Mountain spotted fever and Mediterranean spotted fever, respectively. In patients naturally infected with either of these organisms, antibodies are produced which cross-react with antigens of the other so extensively that diagnostic tests usually cannot identify the causative agents. The results of this study indicate that serodiagnostic tests with antigen from one of these two organisms could be used to detect antibodies in patients with either of the two rickettsial diseases.

Key concepts: Rickettsia rickettsii, Spotted fever, Rickettsia conorii, Rocky Mountain spotted fever, Boutonneuse fever, Antibody, Antigen, Rickettsia

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