2006•Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyRequires access

Plasmodium falciparum Malaria Associated with Mefloquine Failure in Gambia

Erin C Callen, Chelsea O Church

Abstract

A 25-year-old Caucasian man developed Plasmodium falciparum malaria after traveling to Gambia, despite having received chemoprophylaxis with mefloquine. The patient was hospitalized after returning to the United States. He received a 3-day course of atovaquone-proguanil and made a complete recovery. This case illustrates the potential role of pharmacists in the pharmaceutical care of travelers and underscores the importance of using current recommendations for preventing and treating malaria.

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Key concepts: Mefloquine, Malaria, Atovaquone, Plasmodium falciparum, Proguanil, Chemoprophylaxis, Medicine, Malaria prophylaxis