Experience of multiple supplementary doses of vecuronium

Seventy-one supplementary doses of vecuronium were used for muscle relaxation during a 22-h-long NLA II anaesthesia. For assessment of neuromuscular blockade, train-of-four stimulation was used to measure the twitch force of the adductor pollicis after electrical stimulation of the ulnar nerve. No cumulative effect of vecuronium could be demonstrated, measured under strictly controlled conditions. Adding isoflurane 0.5% (end tidal) only slightly prolonged the neuromuscular blocking effect.