The tissue penetration, as measured by a blister technique, and pharmacokinetics of cefsulodin compared with carbenicillin and ticarcillin

Serum and cantharides-induced blister fluid levels of cefsulodin, carbenicillin and ticarcillin were compared in a semi-crossover study, after a I g intravenous bol us injection. The serum concentration/time curves for the three β-lactams were essentially similar, the half-lives being 1·25–1·5 h. Cefsulodin and ticarcillin penetrated into the fluid to a greater extent than carbenicillin. As cefsulodin is a more potent antibiotic against Pseudomonas aeruginosa it is suggested that this may be the agent of choice in treating infections caused by this pathogen.