2014•Memórias do Instituto Oswaldo CruzOpen access
The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
Policarpo Ademar Sales, Celso de Oliveira Rezende Júnior, Mireille Le Hyaric, Mauro Vieira de Almeida, Álvaro J. Romanha
Open full text 12 citations
Abstract
Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).
Open-access reader