2003•Antimicrobial Agents and ChemotherapyOpen access

Influence of Reduced Susceptibility to Glycopeptides on Activities of Vancomycin and Teicoplanin against Staphylococcus aureus in Experimental Endocarditis

Juliette Pavie, A. Lefort, Marie-Cécile Ploy, Laurent Massias, Françoise Chau, Louis Garry, François Denis, B. Fantin

Abstract

The influence of reduced susceptibilities to glycopeptides on the activities of vancomycin and teicoplanin against an isogenic pair of clinical Staphylococcus aureus strains in experimental endocarditis was investigated. While vancomycin was similarly active against both strains, teicoplanin was approximately 100-fold less active against the resistant strain and selected for the emergence of more resistant subpopulations.

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Key concepts: Teicoplanin, Glycopeptide, Vancomycin, Staphylococcus aureus, Microbiology, Endocarditis, Staphylococcal infections, Glycopeptide antibiotic