2008•Clinical and Vaccine ImmunologyOpen access

Development and Characterization of an Equine Infectious Anemia Virus Env-Pseudotyped Reporter Virus

Rebecca L. Tallmadge, Melinda Ann Brindley, J. Salmans, Robert H. Mealey, Wendy J. Maury, Susan L. Carpenter

Abstract

We developed a replication-defective reporter virus pseudotyped with the envelope glycoprotein of equine infectious anemia virus (EIAV). The in vitro host range and neutralization phenotype of EIAV Env-pseudotyped virus were similar to those of replication-competent virus. An EIAV Env pseudovirus will improve antigenic characterization of viral variants and evaluation of lentivirus vaccines.

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Key concepts: Equine infectious anemia, Virology, Virus, Lentivirus, Biology, Viral replication, Glycoprotein, Neutralization