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2006•Protein and Peptide LettersRequires access

Comparative Study of Apoptosis Induced by H2O2 and NO: Limitation of Apoptosis Induced by NO Due to Slower Recovery of Activity of NOModified Caspase

Ja-Eun Kim, Heeyoung Seok, Pratap Karki, Jung Sup Lee, Song Yub Shin, Byungyun Cho, Il‐Seon Park

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Abstract

Both H(2)O(2) and NO can act as apoptogens, triggering apoptosis in many cells. They are also well known inhibitors of caspases, essential enzymes in apoptosis. The differences between these two agents as apoptosis inducers and how caspases mediate apoptosis with these inhibitory agents is still unclear. Consistent with the previous reports, these two agents induced apoptosis accompanied by caspase activation with limitation of all apoptotic events for NO. It was found that NO-modified caspase-3 showed a slower recovery of its activity in the presence of the reducing agents compared to that of H(2)O(2) modification. This is one possible cause of the limited apoptosis in the case of NO.

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What this paper is about

Both H(2)O(2) and NO can act as apoptogens, triggering apoptosis in many cells. They are also well known inhibitors of caspases, essential enzymes in apoptosis. The differences between these two agents as apoptosis inducers and how caspases mediate apoptosis with these inhibitory agents is still unclear. Consistent with the previous reports, these two agents induced apoptosis accompanied by caspase activation with limitation of all apoptotic events for NO. It was found that NO-modified caspase-3 showed a slower recovery of its activity in the presence of the reducing agents compared to that of H(2)O(2) modification. This is one possible cause of the limited apoptosis in the case of NO.

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Available abstract

Both H(2)O(2) and NO can act as apoptogens, triggering apoptosis in many cells. They are also well known inhibitors of caspases, essential enzymes in apoptosis. The differences between these two agents as apoptosis inducers and how caspases mediate apoptosis with these inhibitory agents is still unclear. Consistent with the previous reports, these two agents induced apoptosis accompanied by caspase activation with limitation of all apoptotic events for NO. It was found that NO-modified caspase-3 showed a slower recovery of its activity in the presence of the reducing agents compared to that of H(2)O(2) modification. This is one possible cause of the limited apoptosis in the case of NO.

Key concepts: Apoptosis, Caspase 3, Caspase, Biology, Cell biology, Chemistry, Programmed cell death, Biochemistry

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Comparative Study of Apoptosis Induced by H2O2 and NO: Limitation of Apoptosis Induced by NO Due to Slower Recovery of Activity of NOModified Caspase — Research Paper | ScholarLens