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2006•Mini-Reviews in Medicinal ChemistryRequires access

Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma

Reinoud Gosens, Dedmer Schaafsma, S.Adriaan Nelemans, Andrew J. Halayko

Open publisher page 64 citations

Abstract

In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesnt inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness. Keywords: Airway remodelling, airway smooth muscle, airway inflammation, Y-27632, fasudil

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What this paper is about

In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesnt inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness. Keywords: Airway remodelling, airway smooth muscle, airway inflammation, Y-27632, fasudil

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OpenAlex reports 64 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesnt inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness. Keywords: Airway remodelling, airway smooth muscle, airway inflammation, Y-27632, fasudil

Key concepts: Fasudil, Bronchoconstriction, Airway hyperresponsiveness, Medicine, Asthma, Airway, Immunology, Bronchial hyperresponsiveness

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Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma — Research Paper | ScholarLens