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2001•Angewandte Chemie International EditionRequires access

A Stable DNA Duplex Containing a Non-Hydrogen-Bonding and Non-Shape-Complementary Base Couple: Interstrand Stacking as the Stability Determining Factor

Christine Brotschi, Adrian Häberli, Christian J. Leumann

Open publisher page 113 citations

Abstract

The stabilizing effect of a dG:dC base-pair can also be imparted to a DNA duplex by a non-hydrogen-bonding, non-shape-complementary nucleoside analogue when interstrand stacking interactions come into play. This is the case, for example, with dBP, which has a bipyridyl (BP) residue as a nucleobase surrogate (the picture shows a dBP:dBP pair).

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What this paper is about

The stabilizing effect of a dG:dC base-pair can also be imparted to a DNA duplex by a non-hydrogen-bonding, non-shape-complementary nucleoside analogue when interstrand stacking interactions come into play. This is the case, for example, with dBP, which has a bipyridyl (BP) residue as a nucleobase surrogate (the picture shows a dBP:dBP pair).

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OpenAlex reports 113 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The stabilizing effect of a dG:dC base-pair can also be imparted to a DNA duplex by a non-hydrogen-bonding, non-shape-complementary nucleoside analogue when interstrand stacking interactions come into play. This is the case, for example, with dBP, which has a bipyridyl (BP) residue as a nucleobase surrogate (the picture shows a dBP:dBP pair).

Key concepts: Stacking, Nucleobase, Hydrogen bond, Duplex (building), Chemistry, DNA, Base pair, Residue (chemistry)

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A Stable DNA Duplex Containing a Non-Hydrogen-Bonding and Non-Shape-Complementary Base Couple: Interstrand Stacking as the Stability Determining Factor — Research Paper | ScholarLens