An unusual presentation of adenosquamous carcinoma of gallbladder

Carcinoma of the gallbladder is the most common malignancy of the biliary tract. Although adenocarcinomas account for more than 90% of gallbladder cancers, the incidence of adenosquamous carcinomas (ASCs) is only approximately 5%. ASCs have aggressive biological behavior due to their potential for direct extension into the liver and neighboring structures like stomach, duodenum, and transverse colon. In most cases, the disease would have advanced at the time of diagnosis and the prognosis might be dismal when compared to ordinary adenocarcinoma of the gallbladder. We present here a rare case of ASC of gallbladder in a 59-yr-old female who presented with right upper abdominal pain.