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Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel.

Naoya Kato, Kunitada Shimotohno, Donald VanLeeuwen, Maurice Cohen

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Abstract

RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends. We report here the isolation of cDNA clones of these genomic sequences. The transcripts encode a Krüppel-related zinc finger protein consisting of a unique leader region and more than 12 28-amino-acid finger motifs.

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What this paper is about

RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends. We report here the isolation of cDNA clones of these genomic sequences. The transcripts encode a Krüppel-related zinc finger protein consisting of a unique leader region and more than 12 28-amino-acid finger motifs.

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Available abstract

RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends. We report here the isolation of cDNA clones of these genomic sequences. The transcripts encode a Krüppel-related zinc finger protein consisting of a unique leader region and more than 12 28-amino-acid finger motifs.

Key concepts: Krüppel, Zinc finger, Biology, Provirus, Complementary DNA, PHD finger, Choriocarcinoma, Genetics

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Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. — Research Paper | ScholarLens