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Labile Coagulation Factors in Thawed Fresh Frozen Plasma Prepared by Two Methods

Ram Kakaiya, Edward E. Morse, Sophia Panek

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Abstract

Two preparations of fresh frozen plasma were studied. The plasma from CPDA-1 whole blood units was either frozen within 6 h (FFP-I) or 18-20 h (FFP-II) of phlebotomy. Average activity for factor VIII for FFP-I (n = 6) and FFP-II (n = 19) was 102% and 55%, respectively (p less than 0.01). Average activity for factor V and VII in both products was approximately 100%. Factor XI activity (n = 13) in FFP-II averaged 84%. We conclude that FFP-I and FFP-II are equivalent in terms of coagulation factor activity except for factor VIII.

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What this paper is about

Two preparations of fresh frozen plasma were studied. The plasma from CPDA-1 whole blood units was either frozen within 6 h (FFP-I) or 18-20 h (FFP-II) of phlebotomy. Average activity for factor VIII for FFP-I (n = 6) and FFP-II (n = 19) was 102% and 55%, respectively (p less than 0.01). Average activity for factor V and VII in both products was approximately 100%. Factor XI activity (n = 13) in FFP-II averaged 84%. We conclude that FFP-I and FFP-II are equivalent in terms of coagulation factor activity except for factor VIII.

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Available abstract

Two preparations of fresh frozen plasma were studied. The plasma from CPDA-1 whole blood units was either frozen within 6 h (FFP-I) or 18-20 h (FFP-II) of phlebotomy. Average activity for factor VIII for FFP-I (n = 6) and FFP-II (n = 19) was 102% and 55%, respectively (p less than 0.01). Average activity for factor V and VII in both products was approximately 100%. Factor XI activity (n = 13) in FFP-II averaged 84%. We conclude that FFP-I and FFP-II are equivalent in terms of coagulation factor activity except for factor VIII.

Key concepts: Fresh frozen plasma, Coagulation, Blood preservation, Chemistry, Blood coagulation factors, Cryopreservation, Thrombelastography, Medicine

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