2011•Chemical and Pharmaceutical BulletinOpen access

Cinchona Alkaloids Are Also Produced by an Endophytic Filamentous Fungus Living in Cinchona Plant

Shoji Maehara, Partomuan Simanjuntak, Chinami Kitamura, Kazuyoshi Ohashi, Hirotaka Shibuya

Abstract

We report that the endophytic filamentous fungus Diaporthe sp., isolated from Cinchona ledgeriana and cultivated in a synthetic liquid medium, produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine). This shows that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in endophytic microbe cells.

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Key concepts: Cinchonine, Cinchonidine, Cinchona Alkaloids, Quinidine, Cinchona, Quinine, Chemistry, Fungus