1993•Human Molecular GeneticsRequires access
A microsatellite-based index map of human chromosome 11
M. Litt, Patricia L. Kramer, X.Y. Hauge, J L Weber, Z. Wang, P.J. Wilkle, Matthew S. Holt, Santosh Kumar Mishra, Helen Donis-Keller, Louise Warnich, Andries E. Retief, C. Jones, Jean Welssenbach
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Abstract
We have constructed a continuous index map of 25 microsatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygosities of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 10(5):1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the index map with the cytogenetic map. The map will facilitate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.