2010•Journal of Clinical MicrobiologyOpen access

GeneXpert Captures Unstable Methicillin-Resistant Staphylococcus aureus Prone to Rapidly Losing the mecA Gene

Diana Ciardo, Sibylle Bürger, Michael Payer, Christian R. Lee, Nadine G. McCallum

Abstract

A cefoxitin-susceptible Staphylococcus aureus strain was identified by the Cepheid GeneXpert as methicillin-resistant S. aureus (MRSA). This strain was highly unstable and rapidly lost SCCmec upon subculturing in vitro, indicating that unstable MRSA is best detected by gene amplification-based methods.

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Key concepts: Cefoxitin, GeneXpert MTB/RIF, SCCmec, Staphylococcus aureus, Microbiology, Strain (injury), Micrococcaceae, Methicillin-resistant Staphylococcus aureus