2011•Angewandte Chemie International EditionOpen access
Facile and General Synthesis of Photoactivatable Xanthene Dyes
Laura M. Wysocki, Jonathan B. Grimm, Ariana N. Tkachuk, Timothy A. Brown, Eric Betzig, Luke D. Lavis
Open full text 140 citations
Abstract
Despite the apparent simplicity of the xanthene fluorophores, the preparation of caged derivatives with free carboxy groups remains a synthetic challenge. A straightforward and flexible strategy for preparing rhodamine and fluorescein derivatives was developed using reduced, “leuco” intermediates.
Open-access reader