1955•Experimental Biology and MedicineRequires access
Effect of Hydrocortisone on Acute Pentobarbital Toxicity in Mice.
R. S. Satoskar, J. C. Trivedi
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Abstract
The LD50 for pentobarbital given intraperitoneally in mice was determined. Administration of picrotoxin within a few minutes of the pentobarbital injection decreased mortality so that the LD50 for the pentobarbital was higher in animals receiving picrotoxin. On the other hand, orally or par-enterally administered hydrocortisone did not decrease mortality and seemed to increase susceptibility to pentobarbital.