A case of van wyk-grumbach syndrome.

In boys precocious puberty is defined as the development of secondary sexual characters before 9 year of age. In girls, the development of breasts (thelarche) before 7.5 year, the development of pubic hairs (pubarche) before 8.5 year or menarche before the age of 9.5 year is considered precocious [1]. Hypothyroidism is usually associated with delayed puberty and rarely with precocious puberty [2]. Hypothyroidism with precocious puberty was first described by Kendle in 1905 [3]. Van Wyck and Grumbach reported the association of multi-cystic ovaries with hypothyroidism and precocious puberty [4]. This pathology is more frequently seen in girls. Precocious puberty is always isosexual and characterized by breast enlargement, multicystic ovaries and menstrual bleeding. In boys it may be associated with testicular enlargement and minimal penile enlargement. Herein we report a case of Van WykGrumbach Syndrome.