2015•Journal of Evolutionary Biochemistry and PhysiologyRequires access

Glial fibrillary acidic protein: The component of iintermediate filaments in the vertebrate brain astrocytes

Elena G. Sukhorukova, Д. Э. Коржевский, Olga Sergeevna Alekseeva

Abstract

Glial fibrillary acidic protein (GFAP) refers to the type III intermediate filament proteins and is the essential component of the cytoskeleton in astrocytes of all vertebrates. This review presents current data on the molecular organization of GFAP in a comparative aspect. The results of most relevant studies using immunocytochemical labeling of the protein are summarized. The data on the changes in expression of GFAP in Alexander disease caused by the primary pathology of astrocytes are presented.

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Key concepts: Glial fibrillary acidic protein, GFAP stain, Intermediate filament, Astrocyte, Cytoskeleton, Intermediate Filament Protein, Cell biology, Biology