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2004•Organic LettersRequires access

Bielschowskysin, a Gorgonian-Derived Biologically Active Diterpene with an Unprecedented Carbon Skeleton

Jeffrey Marrero, Abimael D. Rodrı́guez, P. Baran, Raphael G. Raptis, Juan A. Sánchez, Eduardo Ortega‐Barría, Todd L. Capson

Open publisher page 129 citations

Abstract

Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin was shown to exhibit antimalarial activity against Plasmodium falciparum as well as strong anticancer activity against two human cancer cell lines.

About this research paper

What this paper is about

Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin was shown to exhibit antimalarial activity against Plasmodium falciparum as well as strong anticancer activity against two human cancer cell lines.

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OpenAlex reports 129 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin was shown to exhibit antimalarial activity against Plasmodium falciparum as well as strong anticancer activity against two human cancer cell lines.

Key concepts: Gorgonian, Diterpene, Chemistry, Terpene, Stereochemistry, Carbon skeleton, Tetradecane, Cancer cell lines

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