Pharmacokinetics of ketoprofen in healthy horses in Pakistan.

Ketoprofen (KTP) is a non-steroidal anti-inflammatory drug (NSAID), used to alleviate inflammation and rheumatic problems in humans and animals. A single intravenous dose of ketoprofen was administered in eight healthy horses at dose of 3.0 mg/kg body weight through jugular vein. Blood samples (3-5ml) were drawn pre-medication at zero-hr, and then at 0.08, 0.17, 0.25, 0.5, 0.75, 1.0, 2.0, 3.0, 4.0, 6.0, 8.0, 10, 12.0, 24, 48, 60, 72, 84 and 96 hrs post medication. Plasma was separated out. The concentration of KTP in plasma was measured by HPLC (high performance liquid Chromatography) method. By using the plasma concentration versus time data, the pharmacokinetic parameters were calculated through computer based pharmacokinetic software APO. Version 3.02, as Mean ±SEM AUC (Area Under the concentration time Curve) ± µg.h.ml -1 , Cl (Clearance) ± l.hr -1 .kg -1 , t½ (Half Life) ± hr -1 , VD (Volume of Distribution) ± l.kg -1 , VDss (Volume of distribution at Steady State) ± l.kg -1 , and Kel (Elimination Rate Constant) ± l.hr -1 respectively.