Convenient Synthesis of Ibuprofen and Naproxen Aminoacyl, Dipeptidoyl and Ester Derivatives
Alan R. Katritzky, Davit Jishkariani, Tamari Narindoshvili
Abstract
Alan R. Katritzky, Davit Jishkariani, Tamari Narindoshvili
Abstract
DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.
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DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.
Key concepts: Ibuprofen, Naproxen, Chemistry, Prodrug, Yield (engineering), Combinatorial chemistry, Organic chemistry, Pharmacology