2009Chemical Biology & Drug DesignRequires access

Convenient Synthesis of Ibuprofen and Naproxen Aminoacyl, Dipeptidoyl and Ester Derivatives

Alan R. Katritzky, Davit Jishkariani, Tamari Narindoshvili

Open publisher page 30 citations

Abstract

DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.

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What this paper is about

DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.

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OpenAlex reports 30 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.

Key concepts: Ibuprofen, Naproxen, Chemistry, Prodrug, Yield (engineering), Combinatorial chemistry, Organic chemistry, Pharmacology

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