2010•NatureOpen access

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Rajnish A. Gupta, Nilay Shah, Ke Wang, Jeewon Kim, Hugo M. Horlings, David J. Wong, Miao-Chih Tsai, Tiffany Hung, Pedram Argani, John L. Rinn, Yulei Wang, Pius M. Brzoska, Benjamin Kong, Rui Li, Robert B. West, Marc J. van de Vijver, Saraswati V. Sukumar, Howard Y. Chang

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Key concepts: HOTAIR, Biology, PRC2, Hox gene, Chromatin, Epigenome, Cancer research, Metastasis