CHANGES IN THE ADRENAL OF THE HYPOPHYSECTOMIZED C3H MOUSE WITH α-CORTICOTROPIN AND GROWTH HORMONE1

Changes in the adrenal gland of the C3H mouse and in the distribution of lipid therein as a consequence of hypophysectomy were investigated, and replacement therapy with a-corticotropin and growth hormone, alone or in combination, was instituted. 20 days after removal of the pituitary, the adrenal cortex manifested an atrophy similar to that described for other strains of miceand for the rat. α-Corticotropin at daily dose levels of 0.020 mg. and 0.050 mg. given for 7 days restored the zona fasciculata of the cortex and increased the histologically-detectable lipidin the zona glomerulosa. A dose of 0.10 mg. increased the weight of the adrenals by 100 per cent and effected a substantial depletion of sudanophilic lipid from the cortex. After treatment with growth hormone, the adrenal glands were not significantly heavier than those of the untreated hypophysectomized controls.